Effects of a 6-month cardiovascular exercise program on symptomatology, cardiovascular fitness and brain volumes in patients with schizophrenia: a multicentre randomised controlled trial

niversity Medical Center Utrecht (Netherlands)0 个研究点目标入组 160 人开始时间: 2011年9月21日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•Patients must meet the following criteria to be eligible for enrolment:
•1. Diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) and assessed with the Comprehensive Assessment of Schizophrenia and History (CASH) (Andreasen et al., 1992).
•2. 18 - 48 years old
•3. Stable on antipsychotic medication
•4. Written informed consent
•Healthy control subjects must meet the following criteria to be eligible for enrolment:
•1. No diagnosis of a psychiatric disorder according to DSM-IV ever
•2. 18 - 48 years old
•3. Matching amount of physical activity compared to included patients, as measured before intervention by the SenseWear PRO2 Body Monitoring System
•4. Matching level of parental education compared to included patients, as measured before intervention by means of the verhage method
•5. Matching body mass index (BMI) compared to included patients, as measured before intervention
•6. No first degree relative with a psychotic or depressive disorder
•7. Written informed consent

•1. Evidence of significant cardiovascular disorders that might prevent safe participation in the study. Risk of cardiovascular disorders will be assessed following Lausanne recommendations
•2. Evidence of significant neuromuscular or endocrine, or other disorders (for example joint disease) that might prevent safe participation in this study
•3. A primary diagnosis of alcohol or substance abuse
•4. intelligence quotient (IQ) < 70, as measured with Wechsler Adult Intelligence Scale Short Form (WAIS-III SF): short version of the WAIS-III, gives an estimate of an individual?s intellectual functioning.
•5. Organic brain disorder or other clinically significant concurrent medical illness
•6. Severe head trauma
•7. With occurrence of certain medical diseases (for example fever) a subject can be temporarily be excluded from the intervention

发起方

niversity Medical Center Utrecht (Netherlands)