Analysis of microscopic structure and functional connectivity for headache with increasing intracranial pressure
- Conditions
- increasing intracranial pressure
- Registration Number
- JPRN-UMIN000043583
- Lead Sponsor
- Mito Kyodo General Hospital
- Brief Summary
Optic nerve sheath diameter: significantly increased after Head down DTI analysis: No significant difference in FA before and after Head down AD, MD significantly increased after Head down FC: Significant decrease in FC in cerebellum-middle frontal gyrus, inferior frontal gyrus, deltoid and orbitofrontal gyrus after Head down Significantly higher FC before Head down (before headache onset) in the headache group Significantly lower FC in most of the headache group after head down (after headache onset)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Not provided
1. Currently undergoing treatment for an underlying disease 2. Presence of organic intracranial lesions such as cerebrovascular disease or tumor 3. History of chronic headache 4. Pregnant 5.Currently participating or planning to participate in other clinical trials 6. claustrophobia 7. Inappropriate for MRI imaging such as pacemaker or implant
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Headache pattern and intracranial pressure after starting HDBR 10min 2.Fractional Anisotropy (FA) and Functional Connectivity (FC) before and after starting HDBR
- Secondary Outcome Measures
Name Time Method