Glucose metabolism in Familial Hypobetalipoproteinemia.
Completed
- Conditions
- -patients with FHBL and liver steatosis-healthy controls matched for age, BMI, waist circumference and physical activity
- Registration Number
- NL-OMON24590
- Lead Sponsor
- Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 22
Inclusion Criteria
1. Male;
2. Age > 18 y;
Exclusion Criteria
1. Known somatic illness;
2. Use of medication influencing metabolism/ blood clotting;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Insulin sensitivity at the level of glucose production by liver, glucose uptake by muscle+fat and lipolysis; <br /><br>2. Fat distribution by a DEXA-, a CT-scan and MRS-spectroscopy.<br />
- Secondary Outcome Measures
Name Time Method 1. Lipid levels; <br /><br>2. Glucoregulatory levels;<br /><br>3. (Adipo)cytokines.