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临床试验/NCT06998082
NCT06998082尚未招募不适用

A Large Language Model-Driven Multimodal Early Warning Platform for Perioperative Complications in Acute Hemorrhagic Cerebrovascular Disease

Beijing Tiantan Hospital1 个研究点 分布在 1 个国家目标入组 1,533 人开始时间: 2025年7月6日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
1,533
试验地点
1
主要终点
The primary outcome measures were postoperative complications involving the neurological, cardiac, pulmonary, and renal systems in patients with acute hemorrhagic cerebrovascular disease following surgical interventions.

研究概览

简要总结

Acute hemorrhagic cerebrovascular disease is a life-threatening condition characterized by sudden onset, rapid progression, multiple complications, poor prognosis, and high mortality. It presents a significant public health burden. During surgical interventions, precise risk stratification and effective perioperative management are crucial to mitigating intraoperative and postoperative complications, optimizing disease diagnosis, guiding severity assessment, and refining anesthesia strategies. Continuous real-time evaluation and dynamic perioperative adjustments are essential to minimize the influence of institutional variability and individual clinician-dependent decision-making. By harnessing big data-driven, evidence-based medical approaches, clinicians can enhance diagnostic accuracy and therapeutic precision, addressing a critical challenge in reducing morbidity and mortality in this patient population.

This study aims to develop a comprehensive multimodal perioperative database and leverage large language models (LLMs) for the efficient extraction of structured demographic and clinical data throughout the perioperative course. By integrating real-time hemodynamic monitoring parameters, the investigators seek to elucidate the relationship between perioperative hemodynamic patterns and the incidence of postoperative complications affecting major organ systems, including the brain, heart, kidneys, and lungs. The ultimate goal is to construct a multimodal fusion early-warning model capable of real-time, simultaneous prediction of multiple perioperative complications. This AI-driven platform will function as a risk stratification and alert system for organ-specific perioperative complications in patients with acute hemorrhagic cerebrovascular disease. By providing evidence-based insights for optimized perioperative management-encompassing early warning mechanisms, diagnostic support, and individualized therapeutic strategies-the system aims to improve clinical outcomes, reduce perioperative morbidity, and lower overall mortality.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients aged 18 to 80 years.
  • •Diagnosis confirmed by preoperative imaging (CT or MRI) of one of the following conditions:
  • •Intracranial aneurysm
  • •Arteriovenous malformation (AVM)
  • •Hemorrhagic moyamoya disease
  • •Cavernous malformation
  • •Spontaneous intracerebral hemorrhage
  • •Undergoing surgery within seven days of symptom onset.

排除标准

  • •Patients who decline to provide informed consent.
  • •Patients enrolled in conflicting clinical studies.

结局指标

主要结局

The primary outcome measures were postoperative complications involving the neurological, cardiac, pulmonary, and renal systems in patients with acute hemorrhagic cerebrovascular disease following surgical interventions.

时间窗: Within 30 days after surgery

次要结局

未报告次要终点

研究者

发起方
Beijing Tiantan Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Yuming Peng

Deputy chief of Department of Anesthesiology

Beijing Tiantan Hospital

研究点 (1)

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