Optimization of Patients Long-term Management After the Coronavirus Infection COVID-19

• Conditions: Covid19
• Interventions: Diagnostic Test: Laboratory and instrumental examination

• Registration Number: NCT04871789
• Lead Sponsor: Pirogov Russian National Research Medical University

Brief Summary

200 participants should be included in the study. There will be three groups: 100 participants with a severe course of the disease 3 months ago, 50 asymptomatic carriers of coronavirus infection 3 months ago and 50 people who were in close contact with patients with confirmed coronavirus infection 3 months ago, but not sick and without antibodies to SARS-CoV-2.

The study consists of two visits. At the first visit, after signing the consent to participate in the study, a screening examination will be performed to assess the criteria for inclusion and exclusion in the study.

At the second visit, patients who meet the inclusion criteria and do not have exclusion criteria will undergo clinical and instrumental examination, and biological samples will be collected for laboratory testing.

The aim of the study is to determine the most significant clinical and laboratory markers of the severity of the outcomes in the period of convalescence of the new coronavirus infection COVID-19. Clinical and laboratory indicators, the number and severity of signs of postcovid syndrome as well as pathological changes in lung tissue according to CT data in the group with covid pneumonia and indicators of immune status, hemostasis, endothelial dysfunction, inflammation, metabolism will be assessed.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-20
• Status Verified: 2021-03
• Study First Submitted: 2021-03-21
• Study First Submitted QC: 2021-05-01
• Last Update Submitted: 2021-05-01
• Study First Posted: 2021-05-04
• Last Update Posted: 2021-05-04
• Primary Completion: 2021-05-15
• Study Completion: 2021-06-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

For all groups:

• Informed consent signed by the patient.
• Men and women aged 18 and over.

Group COVID-19 (asymptomatic):

• Confirmed diagnosis of COVID-19 (positive SARS-CoV-2 RNA PCR test or history of IgM and / or IgG antibodies to SARS-CoV-2)
• Absence of any clinical symptoms associated with coronavirus infection.

Group Healthy:

• Contact with patients with symptomatic new coronavirus infection COVID-19 in the absence of personal protective equipment for at least 3 days.
• Absence of any clinical symptoms associated with coronavirus infection

Group COVID symptomatic:

• Confirmed diagnosis of previous COVID-19 (positive SARS-CoV-2 RNA PCR test or presence of IgM antibodies to SARS-CoV-2) in history.

• A severe course of COVID-19, characterized by one or more of the following symptoms:

  • Respiratory rate ≥ 30 in 1 min
  • Blood oxygen saturation (SpO2) ≤ 93%
  • The ratio of the partial tension of oxygen in arterial blood to the fraction of oxygen during inspiration (PaO2 / FiO2) <300
  • Lung tissue lesion> 50% and / or according to computed tomography CT-2 and higher
  • Septic shock / sepsis
  • Development of multiple organ failure
  • Cytokine storm

Exclusion Criteria

• Pregnancy
• Covid-19 vaccination
• Any serious medical illness before coronavirus infection, as well as a permanent form of atrial fibrillation
• Regular intake of anti-inflammatory, antibacterial, cytostatic and immunosuppressive drugs
• Refusal to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with severe COVID-19 pneumonia	Laboratory and instrumental examination	-
People who had close contact with patients with confirmed COVID-19 3 months ago but did not get sick	Laboratory and instrumental examination	-
Patients who had an asymptomatic COVID-19 3 months ago	Laboratory and instrumental examination	-

Primary Outcome Measures

Name	Time	Method
The presense of postcovid syndrome	through study completion, an average of 3 months	Clinical and laboratory indicators The number and severity of signs of postcovid syndrome

Secondary Outcome Measures

Name	Time	Method
Pathological changes in lung tissue according to CT data	through study completion, an average of 3 months	CT scan

Trial Locations

Locations (1)

Russian Clinical Research Center for Gerontology; 🇷🇺 Moscow, Russian Federation