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Clinical Trials/NCT04430764
NCT04430764CompletedNot Applicable

The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels

Ege University0 sites58 target enrollmentStarted: October 1, 2014Last updated:
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Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
58
Primary Endpoint
Change in gingival crevicular fluid EMMPRIN total amounts
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis. Twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. Non-surgical periodontal treatment was applied to all periodontitis patients. Periodontal parameters and GCF CyPA and EMMPRIN levels were evaluated during 3 months following non-surgical periodontal treatment. GCF CyPA and EMMPRIN levels were analyzed by ELISA.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
Single (Outcomes Assessor)

Eligibility Criteria

Ages
29 Years to 61 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •generalized periodontitis with stage III-IV & Grade B
  • •no systemic and periodontal diseases
  • •smokers (minimum 10 cigarettes per day for at least ten years)
  • •non-smokers (never smoked)

Exclusion Criteria

  • •Systemic diseases
  • •Infectious diseases
  • •Pregnancy or lactating
  • •Having periodontal treatment during the last 6 months
  • •Having antibiotic treatment within the past 3 months
  • •Former smokers

Arms & Interventions

smoker

Experimental

Intervention: non-surgical periodontal treatment (Procedure)

non-smoker

Active Comparator

Intervention: non-surgical periodontal treatment (Procedure)

Outcomes

Primary Outcomes

Change in gingival crevicular fluid EMMPRIN total amounts

Time Frame: Baseline, 1 week, 1., 3. months

GCF EMMPRIN levels were analyzed by ELISA

Change in gingival crevicular fluid CypA total amounts

Time Frame: Baseline, 1 week, 1., 3. months

GCF CyPA levels were analyzed by ELISA

Secondary Outcomes

  • Change in bleeding on probing(Baseline, 1., 3. months)
  • Change in probing depth(Baseline, 1., 3. months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Oya Turkoglu

Professor

Ege University

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