Electrophysiological phenotypes of cognition and behaviour, a pilot study to obtain translational phenotypes
Completed
- Conditions
- psychiatric disorders10037176
- Registration Number
- NL-OMON36607
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 280
Inclusion Criteria
- Subjects must fit in one of the groups that are investigated.
- Age >=18 and able to give consent
- Inclusion of patients with all Dutch ancestry (at least three of the four grandparents from the Netherlands)
- previous participation in studies, in which the participant has consented to be aproached for other studies
Exclusion Criteria
- Age <18
- Premorbid IQ <80
- Presence of major somatic illness
- Current treatment or detention under the Dutch governmental mental health act.
- Participants that can not read, speak or understand Dutch.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are obtained from electrophysiological data,<br /><br>including spectral analysis of frequency bands during resting state, Event<br /><br>Related Potentials, like P50, PPI and P300, but also connectivity with<br /><br>coherence, and graph theory analysis. Correlations with behavioural and<br /><br>cognitive measures will be explored, as well as associations with candidate<br /><br>genes or genomic measures, like gene-expression, copy number variants and<br /><br>chromosomal strains.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>