Effects of Phenolic Acids on Endothelial Function

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT01772784
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Study First Submitted: 2012-07-25
• Status Verified: 2012-11
• Primary Completion: 2012-11
• Study Completion: 2012-11
• Study First Submitted QC: 2013-01-17
• Last Update Submitted: 2013-01-17
• Study First Posted: 2013-01-21
• Last Update Posted: 2013-01-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Healthy
• males
• Smokers

Exclusion Criteria

Any food allergy

• Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
• Regular consumption of medication within 2 months before the study inclusion
• Caffeine intake 1 day before screening measurements (and 1 day before each visit),
• Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
• Excessive alcohol intake defined as > 280 g per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
endothelial dysfunction	1 hour

Trial Locations

Locations (1)

Swiss Cardiovascular Center Bern, University Hospital; 🇨🇭 Bern, Switzerland