Study of the Impact of Pharmaceutical Interventions on the Medication Adherence of Epileptic Patients and Their Medication Knowledge
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Medication Possession Ratio (MPR)
研究概览
简要总结
Many studies have reported a disparity in medication adherence among epileptic patients. In this population, Medication Possession Ratio (MPR) is an index of medication adherence. MPR is defined as the ratio of the number of days of treatment delivered to the number of days in the period of interest.
No-adherents patients are defined by a MPR of less than 80% , in whom an increase in seizures and the rate of hospitalization can be observed. A pharmacist-led intervention and medication information to epileptic patients could improve patient medication adherence to antiepileptic drugs, and possibly decrease the frequency of seizures, hospitalizations and the health costs generated by these hospitalizations. This intervention could also improve patient knowledge about their medications.
The aim of this study is to evaluate the effectiveness of a pharmacist-led intervention on medication adherence of epileptic patients with the MPR. Secondary objectives include the comparison of medication adherence with health insurance score, the evaluation of patients knowledges about their medications, community pharmacists' satisfaction about community hospital network, the comparison of the seizure free patient rate and the comparison of the rate of patient in whom seizure have decreased by 50%
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Epileptic patients seeing a neurologist in the neurophysiology clinic with a regular follow-up by the Lille University Hospital reference center
- •Adult over 18 years old
- •Living at home
- •Socially insured patient
- •In the case of cognitive problems, the presence of a reliable caregiver managing the medications
排除标准
- •Inpatients
- •Patient under curatorship, guardianship and/or institutionalized
- •Patient who has participated in a therapeutic education program (TEP) about his epilepsy within the previous two years
- •Administrative reasons: impossibility to receive informed information, impossibility to participate in the entire study, lack of coverage by the social security system, refusal to sign the consent form.
- •Switching to home care by a registered nurse for treatment management
结局指标
主要结局
Medication Possession Ratio (MPR)
时间窗: at 3 months after inclusion
Compare adherence to antiepileptic drugs between patients who received pharmacist led intervention and those who did not by Medication Possession Ratio (MPR) 3 months after inclusion
次要结局
- Rate of MPR >80 percent(at 3 months and 6 months)
- Assessment of health insurance score (Score 0 to 6)(at 3 months and 6 months)
- Medication Possession Ratio (MPR)(at 6 months after inclusion)
- Rate of patient in whom seizure have decreased by 50 percent(at 6 months)
- Pharmaceutical interview measured by responses to the knowledge Questionnaire (10-point score)(at 1 hour, 3 months and 6 months)
- Satisfaction score on a Likert scale (score 1 to 5)(at 3 months and 6 months)
- Rate of patients with no seizures(at 6 months)