Impact of Pharmaceutical Interviews on the Medication Adherence of Epileptic Patients
- Conditions
- Epilepsy
- Interventions
- Other: Pharmacist interventionOther: Standard of care
- Registration Number
- NCT04876820
- Lead Sponsor
- University Hospital, Lille
- Brief Summary
Many studies have reported a disparity in medication adherence among epileptic patients. In this population, Medication Possession Ratio (MPR) is an index of medication adherence. MPR is defined as the ratio of the number of days of treatment delivered to the number of days in the period of interest.
No-adherents patients are defined by a MPR of less than 80% , in whom an increase in seizures and the rate of hospitalization can be observed. A pharmacist-led intervention and medication information to epileptic patients could improve patient medication adherence to antiepileptic drugs, and possibly decrease the frequency of seizures, hospitalizations and the health costs generated by these hospitalizations. This intervention could also improve patient knowledge about their medications.
The aim of this study is to evaluate the effectiveness of a pharmacist-led intervention on medication adherence of epileptic patients with the MPR. Secondary objectives include the comparison of medication adherence with health insurance score, the evaluation of patients knowledges about their medications, community pharmacists' satisfaction about community hospital network, the comparison of the seizure free patient rate and the comparison of the rate of patient in whom seizure have decreased by 50%
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 248
- Epileptic patients seeing a neurologist in the neurophysiology clinic with a regular follow-up by the Lille University Hospital reference center
- Adult over 18 years old
- Living at home
- Socially insured patient
- In the case of cognitive problems, the presence of a reliable caregiver managing the medications
- Inpatients
- Patient under curatorship, guardianship and/or institutionalized
- Dementia
- Patient who has participated in a therapeutic education program (TEP) about his epilepsy within the previous two years
- Administrative reasons: impossibility to receive informed information, impossibility to participate in the entire study, lack of coverage by the social security system, refusal to sign the consent form.
- Switching to home care by a registered nurse for treatment management
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Pharmacist-led intervention Pharmacist intervention - Standard of care Standard of care -
- Primary Outcome Measures
Name Time Method Medication Possession Ratio (MPR) at 3 months after inclusion Compare adherence to antiepileptic drugs between patients who received pharmacist led intervention and those who did not by Medication Possession Ratio (MPR) 3 months after inclusion
- Secondary Outcome Measures
Name Time Method Rate of MPR >80 percent at 3 months and 6 months Compare the rate of adherent patients rate (MPR \> 80 percent) between the two arms at 3 and 6 months
Assessment of health insurance score (Score 0 to 6) at 3 months and 6 months Compare drug adherence via the health insurance score between the 2 arms
Medication Possession Ratio (MPR) at 6 months after inclusion Compare adherence to antiepileptic drugs between patients who received pharmacist led intervention and those who did not by Medication Possession Ratio (MPR) 6 months after inclusion
Rate of patient in whom seizure have decreased by 50 percent at 6 months Compare the rate of patient in whom seizure have decreased by 50 percent between the two arms
Pharmaceutical interview measured by responses to the knowledge Questionnaire (10-point score) at 1 hour, 3 months and 6 months Evaluate the development (before vs after led pharmacist intervention) and maintenance of patient knowledge of patients received pharmacist intervention and compare them to the patient knowledge who received conventional management.
Satisfaction score on a Likert scale (score 1 to 5) at 3 months and 6 months Evaluate the satisfaction of community pharmacist about community hospital network by a satisfaction questionnaire in the intervention group
Rate of patients with no seizures at 6 months Compare the rate of seizure free patients between the two arms
Trial Locations
- Locations (1)
Hopital Roger Salengro, CHU Lille
🇫🇷Lille, France