Patient-derived Stem Cell Models of Anorexia Nervosa
- Conditions
- Anorexia Nervosa
- Interventions
- Other: observational
- Registration Number
- NCT06259500
- Lead Sponsor
- Karolinska Institutet
- Brief Summary
Experimental and genetic data, as well as brain imaging, support a role of the hypothalamic Arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been possible to explore these cells at a molecular level in anorexia nervosa (AN) patients. This attributed to the obvious lack of valid tissue and non-invasive imaging techniques of high enough resolution. Stem cell models have evolved as a useful tool for the exploration of other neuropsychiatric disorders with a comparably high genetic contribution as AN. The investigators will here use patient-derived induced pluripotent stem cells (iPSCs) to profile Arc neurons and peripheral blood mononuclear cell (PBMC) derived microglia in AN, thus defining molecules to explore as drug targets.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 20
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description anorexia nervosa observational - healthy controls observational -
- Primary Outcome Measures
Name Time Method Arcuate neuron function and transcriptomic profiling 2026 Electrical activity, transmitter release and whole transcriptomic profiling of iPSC derived Arcuate neurons, anorexia nervosa vs healthy controls
Microglia function and transcriptomic profiling 2025 phagocytic and immune activation capacity and whole transcriptomic profiling, anorexia nervosa vs healthy controls
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Karolinska Institutet
🇸🇪Stockholm, Sweden