A Double Blind Placebo Controlled Study On The Neuroprotective And Anti-Atherogenic Effects Of Palm TocotrienolRich Fraction(Palm Vitamin E)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 241
- 试验地点
- 2
- 主要终点
- Regression of white matter lesion load in terms of numbers and size in the brain
研究概览
简要总结
The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance imaging (MRI), carotid artery magnetic resonance angiography (MRA) and liver ultrasound (US) as well as lipid profile analysis.
详细描述
Stroke is the third largest cause of death after heart disease and cancer in Malaysia. It is estimated that 52,000 Malaysians suffer stroke annually. In 2005, 3245 cases of stroke were fatal. It is projected that the number of fatal stoke cases will exceed 25,000 in 2020.
It was found that at nanomolar concentrations, α-tocotrienol but not α-tocopherol prevent glutamate-induced neuron cell death in mice through inhibition of c-Src kinase and 12-lipoxygenase. Tocotrienol-supplemented rats showed more protection against stroke-induced injury compared with matched controls.
White matter lesion as detected on magnetic resonance imaging (MRI) is closely related to vascular events of the brain. MRI and histopathological study has shown that the larger white matter lesions not usually conforming to usual areas infarcts can actually represent areas of subclinical infarct. In addition there is positive correlation between white matter lesions with established vascular risk factors.
The Rotterdam Scan Study showed that elderly people with silent brain infarcts and white matter lesions are at a strongly increased risk of clinical stroke, which could not be explained by the major stroke risk factors alone.
Several recent studies showed that white matter lesions may be an independent prognostic measure of future stroke risk.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant able to understand and has signed and dated the Informed Consent Form
- •Participant can be either a male or female
- •Participant is more than 35 years of age
- •Participant has total cholesterol between 5.2 - 6.2 mmol/L and LDL cholesterol between 2.6 - 4.2 mmol/L
- •Participant is able to comply with visits and medications
- •Participant has normal liver function (total protein, total albumin, total globulin, total bilirubin, SGOT and SGPT)
- •Participants who satisfy the Inclusion and Exclusion Criteria for Study in General with one or more of the following conditions will be eligible for MRI screening:
- •More than 40 years of age
- •Stable hypertension requiring only out-patient management
- •Diabetes mellitus requiring only out-patient management
- •Ischaemic heart disease requiring only out-patient management
- •Body mass index more than 25 (overweight or obese)
排除标准
- •Female participants who are pregnant
- •Participant has previously received vitamin E supplementation (tocotrienols or tocopherols) within the past 3 months at the time of recruitment
- •Participant has a history of cancer or has undergone radiation therapy
- •Participant has a history of major organ dysfunction, such as moderate or severe hepatic impairment, severe renal insufficiency, severe or unstable cardiovascular, respiratory, hematological, endocrinological, neurological or other somatic disorders resulting in previous hospitalization.
- •Participant has a neurological impairment or psychiatric disorder preventing his understanding of consent and his ability to comply with the protocol.
- •Participant is requiring long term anti-epileptics, hypnotics, and chronic medications for hypercholesterolemia
- •Participant has very high cholesterol levels, total cholesterol above 6.2 mmol/L and LDL cholesterol above 4.2 mmol/L, which require medical treatment.
- •Participant is requiring long term non-steroidal anti-inflammatory (NSAID) medication.
- •Participant has a history of hypersensitivity to vitamin E.
- •Participant has signs of alcohol and drug dependence or abuse.
- •Participant is unable to understand and comply with the elements in the consent form.
- •In addition, the participant must not have any contraindication to have MRI examinations including:
- •Biostimulators (e.g. cardiac pacemaker and implanted spinal cord stimulator)
- •Neurostimulators
- •Aneurysm clips in the brain
- •Cochlear implants
- •Hearing aids
- •Orthopaedic implants less than 2 months old
- •Metal fragments in eyes Any further implants or foreign body not listed above should have the safety assessed by a radiologist prior to recruitment into the MRI study.
结局指标
主要结局
Regression of white matter lesion load in terms of numbers and size in the brain
时间窗: 1 to 2 years
次要结局
- The improvement in the lipid profile other markers associated with increased cardiovascular risk(1 to 2 years)
- Regression of the carotid artery stenoses in terms of percentage(1 to 2 years)
- Improvement in liver echogenicity.(1 to 2 years)
研究者
Yuen Kah Hay
Professor
Universiti Sains Malaysia