HIV-1 and Brain Interaction on Smoking Comorbidity
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Functional and structural connectivity using magnetic resonance imaging (MRI)
研究概览
简要总结
People living with HIV-1 have high rates of cigarette smoking, which may be related to nicotinic interaction with HIV-1 infection and brain function levels. The proposed project aims to understand these pathways using translational brain imaging and HIV-1 reactivation studies. The study proposes a targeted nicotine-brain investigation of the nicotinic effects in HIV-1 infection from cellular to brain circuitry levels.
详细描述
Smoking remains the leading cause of preventable morbidity and mortality in the United States. The alarmingly high smoking rates and unsatisfactory performance of standard smoking cessation efforts in people living with HIV/AIDS (PLWH) interfere with the overall progress in the treatment of HIV-1 infection. Our understanding of nicotine addiction mechanisms in PLWH, and how they are related to and interact with HIV-1 neuropathology, is limited and thus hindering the development of more effective, targeted treatments. The study will directly address neurological complication of this HIV-associated comorbidity at the brain circuitry level using state-of-the-art imaging tools and methods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects between ages 18-60 in good health
- •Ability to give written informed consent
- •For people living with HIV: should be diagnosed with HIV two years or more and on ART two years or more
- •For people living with HIV: should have achieved virologic suppression (defined as viral loads of ≤ 200 copies/ml), and without current signs of reactivation
排除标准
- •Inability to sign informed consent
- •Unable to undergo MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts) or claustrophobic to the scanner
- •Any major medical illnesses to include, but not limited to, uncontrolled high blood pressure or high blood sugar, cardiovascular disease, asthma, peripheral vascular diseases, coagulopathies, history of superficial or deep vein thrombosis as per medical history
- •Current substance-induced psychiatric disorders
- •Significant alcohol or other drug use, other than nicotine dependence or marijuana use
- •Gross structural abnormalities and/or have a history of syncope
- •Positive urine pregnancy tests
- •Any neurological illnesses to include, but not limited to, seizure disorders, multiple sclerosis, movement disorders, or history of head trauma, CVA, CNS tumor,
- •For people living with HIV: having AIDS or non-AIDS-defining cancer or active CNS and other opportunistic disease
- •For people living with HIV: on active treatment of hepatitis C virus (HCV)
结局指标
主要结局
Functional and structural connectivity using magnetic resonance imaging (MRI)
时间窗: one day
Resting functional MRI and diffusion imaging MRI
次要结局
- HIV-1 reactivation(one day)
研究者
L. Elliot Hong
MD
University of Maryland, Baltimore