Different trajectories for people with acute neck pain: associations with biological, psychosocial and treatment-related factors.
- Conditions
- Acute non-specific neck pain
- Registration Number
- NL-OMON29268
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Non-specific neck pain patients will be eligible for participation if they are: 1) at least 18 years old, 2) within 2 weeks of onset of an acute neck pain episode, 3) lasting for >24h, 4) having sufficient knowledge of the Dutch language.
A potential participant who meets any of the following criteria will be excluded from participation in this study:
•Pregnancy or postpartum for not more than 9 months or those who give breastfeeding;
•Contra-indications for venipuncture (e.g. phlebitis);
•Taking one of the following medications during the last 6 weeks: corticosteroids (e.g. prednisone), immunomodulatory medication (e.g. methotrexate, infliximab) and the use of botox for the last 3 months;
•Current participation in another clinical trial;
•Having a medical disease with immune system involvement (e.g. MS, Spondylitis Ankylpoetica).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method atent trajectories whereby participants will be categorized based on their 2-, 4-, 6- weeks and 3-, 6- months NPRS and NDI score.
- Secondary Outcome Measures
Name Time Method The participants will be checked for differences between trajectories in inflammatory markers, psychosocial factors, clinical characteristics and treatment related factors. Questionnaires will be filled in using paper questionnaires. <br><br>Inflammatory markers: Serum levels of high-sensitive CRP, TNF-a and salivary cortisol awakening response (CAR).<br>Psychosocial: catastrophising (PCS), anxiety, depression, stress (DASS21), sleep (PSQI), work, sports, physical activity (IPAQ), Illness perception (IPQ), kinesiophobia (Tampa).<br>Clinical characteristics: pain intensity (NPRS), disability (NDI), pain pressure threshold (PPT), wind-up, condition pain modulation (CPM), global perceived effect (GPE), range of motion (CROM).<br>Treatment related factors: Given treatment, number of treatments, medication use, used diagnostics (e.g. MRI, X-ray).<br>