Amino Acid Balance During Physical Inactivity

Not Applicable

Completed

• Conditions: Assessing Muscle Amino Acid Balance
• Interventions: Other: High-fat overfeeding; Other: Forearm immobilization

• Registration Number: NCT02980952
• Lead Sponsor: University of Exeter

Brief Summary

The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.

Detailed Description

The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.

Study Timeline

• Study First Submitted: 2016-11-30
• Study First Submitted QC: 2016-12-01
• Study First Posted: 2016-12-02
• Study Start: 2017-01
• Primary Completion: 2018-09
• Study Completion: 2018-09
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-23
• Last Update Posted: 2018-10-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 22

Inclusion Criteria

• BMI between 18 and 30

Read More

Exclusion Criteria

• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
• Any diagnosed cardiovascular disease or hypertension.
• Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
• Chronic use of any prescribed or over the counter pharmaceuticals.
• Regular use of nutritional supplements (e.g. creatine, protein supplementation)
• Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
• A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
• Any previous motor disorders.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-fat overfeeding	Forearm immobilization	Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
High-fat overfeeding	High-fat overfeeding	Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
Energy-balanced diet	Forearm immobilization	Forearm immobilization whilst consuming an energy-balanced diet

Primary Outcome Measures

Name	Time	Method
Muscle amino acid balance	3 hours	Forearm muscle amino acid balance

Secondary Outcome Measures

Name	Time	Method
Glucose uptake	3 hours	Forearm glucose uptake