Amino Acid Balance During Physical Inactivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 主要终点
- Muscle amino acid balance
研究概览
简要总结
The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.
详细描述
The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI between 18 and 30
排除标准
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
- •Any diagnosed cardiovascular disease or hypertension.
- •Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
- •Chronic use of any prescribed or over the counter pharmaceuticals.
- •Regular use of nutritional supplements (e.g. creatine, protein supplementation)
- •Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
- •A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
- •Any previous motor disorders.
研究组 & 干预措施
Energy-balanced diet
Forearm immobilization whilst consuming an energy-balanced diet
干预措施: Forearm immobilization (Other)
High-fat overfeeding
Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
干预措施: Forearm immobilization (Other)
High-fat overfeeding
Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
干预措施: High-fat overfeeding (Other)
结局指标
主要结局
Muscle amino acid balance
时间窗: 3 hours
Forearm muscle amino acid balance
次要结局
- Glucose uptake(3 hours)