Oculomotor Deficits in Parkinson's Disease: Enhancing Eye Movement Performance and Dynamic Visual Acuity With Oculomotor Training Using a Pilot Randomized Clinical Trial Design
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Smooth Vergence eye movements
Study Overview
Brief Summary
Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD.
Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases.
In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 40 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage
- •1 to 4 (Hoehn and Yahr Classification)
- •Able to speak and comprehend Cantonese dialect
- •Able to travel independently
Exclusion Criteria
- •Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc)
- •Severe medical problems (e.g. stroke)
- •Cognitive impairment (e.g. dementia)
- •Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment
- •Receiving any medication that is known to affect eye movement and cognitive function
- •Previous formal vision rehabilitation or oculomotor intervention
Arms & Interventions
Control Group
Receive 10 sessions of 45-minute (3 sessions per week) in-office leisure activities e.g. simple non-action computer games or board games (e.g. card and chess games) and 10-20 minutes of video watching at home
Intervention: Control Group (Other)
Intervention Group
Receive 10 sessions of 45-minute office training (3 sessions per week) and 10-20 minute home training (3 sessions per week) of eye movement training
Intervention: Oculomotor Training Group (Other)
Outcomes
Primary Outcomes
Smooth Vergence eye movements
Time Frame: Change from baseline at week 4 and change from baseline at week 12
Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds
Secondary Outcomes
- Oculomotor characteristics(Change from baseline at week 4 and change from baseline at week 12)
- Sentence reading performance(Change from baseline at week 4 and change from baseline at week 12)
- Passage reading performance(Change from baseline at week 4 and change from baseline at week 12)
Investigators
Allen MY Cheong
Associate Professor
The Hong Kong Polytechnic University