Duration of Antibiotic Therapy in Neonatal Gram Negative Bacterial Sepsis -10 days vs. 14 days: a Randomized Controlled Trial

ONE0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Neonates with gestational with birth weight > 1500 g, who satisfy all the following criteria will be enrolled:
•i.Clinical signs of sepsis as per NEOKISS criteria present before antibiotic therapy (Appendix I) in addition to other signs
•ii.Blood culture showing growth of a pathogenic GNB
•iii.Repeat blood culture after 7 days of sensitive antibiotic therapy should be sterile
•iv.Infant should be in remission defined as being on full feeds, not on mechanical ventilation (except high flow nasal cannulae) or on inotropes.

•The following patients will be excluded:
•1.Infants born with major congenital malformations such as diaphragmatic hermia, abdominal wall defects, neural tube defects, esophageal atresia with/without fistula etc.
•2.Severe birth asphyxia (defined as APGAR score <3 at 5 minutes).
•3.Infants being planned to be treated for neonatal meningitis as per attending neonatologist [ ].
•4.Those undergoing or underwent major surgeries.
•5.Infants with clinically evident bone (osteomyelitis) / joint (arthritis) [1].
•6.Infants whose blood cultures were interpreted as â??contaminant or possible contaminantâ??.
•7.Refusal of consent or unlikely to follow up for 28 days.

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