Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection

Not Applicable

Recruiting

• Conditions: Thoracic Surgery; Video-Assisted; Cryotherapy Effect; Paravertebral Block

• Registration Number: NCT05896150
• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-5-19
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Inclusion Criteria:<br><br> - Patients scheduled for elective anatomical pulmonary resection (anatomical<br> segmentectomy, lobectomy or bilobectomy) by VATS for lung cancer<br><br> - American Society of Anesthesiologists (ASA) score 1-3<br><br>Exclusion Criteria:<br><br> - Contraindication to the paravertebral block (coagulopathy, discontinuous<br> paravertebral space, impossible thoracoscopic visualization of the paravertebral<br> space)<br><br> - Contraindication to intercostal cryoanalgesia (cold urticaria, cryoglobulinemia)<br><br> - Epidural analgesia preferred (high risk of thoracotomy, marginal lung function)<br><br> - Surgical criteria (conversion to thoracotomy, non anatomical wedge resection)<br><br> - Known allergy to acetaminophen, celecoxib, sulfa or both hydromorphone and morphine<br><br> - Preoperative thoracic or shoulder pain on the operated side<br><br> - History of thoracic surgery on the operated site<br><br> - Regular use of opioids or medication with effects against neuropathic pain<br> (tricyclics, gabapentinoids, duloxetine, venlafaxine)<br><br> - Inability to understand pain scales or to communicate clearly despite adequate<br> teaching<br><br> - Contraindication to non-steroidal anti-inflammatory drugs (renal filtration rate <<br> 60 mL/min, active gastric ulcer)<br><br> - Pregnancy<br><br> - Patient refusal to participate

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute thoracic pain during cough

Secondary Outcome Measures

Name	Time	Method
Acute thoracic pain at rest;Acute thoracic pain during cough;Postoperative morphine-equivalents consumption;QoR-15 score : 0 (worst) to 150 (best);Hypoesthesia over the ipsilateral thorax;Incidence of nausea related to opioid consumption;Time to hospital discharge;Evaluation of sedation related to opioid consumption;Incidence of vomiting related to opioid consumption;Incidence of pruritus related to opioid consumption