Influence of Emotion and Motivation on Behaviour and Neural Activity in Patients With Psychosis
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen
研究概览
简要总结
Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia
排除标准
- •addiction problem
- •invalidating visual sensory problems
- •neurological history
- •for the healthy volunteers: psychiatric history
结局指标
主要结局
Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen
时间窗: During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120)
Before each cognitive trial a primer will be displayed, which will be either neutral or convey emotion or motivation. The investigators will check whether this primer affects the subjects preparation by measuring the CNV, which is an evoked potential recorded with electroencephalography, and indexing preparatory effort.
次要结局
- Change in the amplitude of the LPP (Late Positive Potential) as a function of the primer displayed on the screen(During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120))