On the Role of The (Pro)Renin-Angiotensin System in Preeclampsia

Recruiting

• Conditions: preeclampsia; 10026908; toxicosis of pregnancy

• Registration Number: NL-OMON32502
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

pregnant women who undergo a caesarian section.
women with and without preeclampsia and with or withour preexistent or gestational diabetes mellitus are included.
Non-pregnant women who undergo abdominal gynaecological surgery

Exclusion Criteria

Not willing to give informed consent
Use of antihypertensive medication

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess whether concentrations of renin and prorenin in the circulation and<br /><br>amniotic fluid change during preeclampsia and whether circulating and amniotic<br /><br>fluid concentrations are inversely related.<br /><br>To assess whether concentrations of renin and prorenin are infuenced by<br /><br>diabetes mellitus.<br /><br>To assess the gene expression of components of the RAS, including the<br /><br>(pro)renin-receptor in the maternal and foetal part of the placenta and the<br /><br>influence of preeclampsia and diabetes mellitus.<br /><br>To assess the functional role of (pro)renin-receptors in the endometrium.<br /><br>To assess the influence of pregnancy and preeclampsia on the role of the<br /><br>angiotensin II, subtype 2 receptor. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>