sing patient-derived neurons to investigate the molecular and cellular basis of Major Depressive Disorder

Completed

Conditions: depression
Major depressive disorder
10027946

Registration Number: NL-OMON40060

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

A. Inclusion criteria for probands:
1. All subjects must give signed, informed consent.
2. Probands must have a DSM-IV consensus diagnosis of Major depressive disorder (MDD) or mood disorder with psychotic features.
3. Patients must have a positive outcome of Dexamethasone suppression test (DST): >=5 microgram/dl.
4. When age >= 65, the first depressive episode must have been before the age of 65.
5. Subjects must be over 18 years of age at interview, male or female.;B Inclusion criteria for healthy family members of probands:
1. First-, second-, or third degree biological family member of participating probands. As for the probands, family members must give signed, informed consent and be over 18 years of age at interview.
2. Healthy family members must have a negative outcome of Dexamethasone suppression test (DST): <5 microgram/dl.

Exclusion Criteria

A Exclusion criteria for probands:
1. Unable to give informed consent to all aspects of the study.
2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews).
3. The depressive disorder is deemed secondary to causative factors, such as medication, general medical condition or substance use.
4. Severe neurological diseases, or other severe co-morbid psychiatric disorders.
5. Pregnancy.;B Exclusion criteria for healthy family members of probands:
1. Unable to give informed consent to all aspects of the study.
2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews).
3. Unwilling to be informed about accidental findings such as aberrant cortisol levels (<50 nmol/l of >800 nmol/l, source NKVC) or aberrant outcome of the other assessments.
4. Severe medical illness, substance abuse, or co-morbid psychiatric disorders.
5. Pregnancy.