Randomized comparison of oophorectomy or not in conjunction with radical cystectomy in wome

Not Applicable

• Conditions: Bladder cancer treated with radical cystectomy; Cancer; Malignant neoplasm of bladder

• Registration Number: ISRCTN18217210
• Lead Sponsor: und University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-24
• Last Update Posted: 19 December 2023
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 360

Inclusion Criteria

1. Women undergoing radical cystectomy
2. Aged 18-85 years

Exclusion Criteria

1. Clinical suspicion of tumour involvement of either ovaries
2. Previous radiation of the pelvis
3. Previous cystectomy
4. Previous oophorectomy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Sexual function, measured using Female Sexual Function Index (FSFI) score at baseline, 12 and 52 weeks postoperatively <br>2. Hormonal status, measured using plasma levels of total testosterone, dihydrotestosterone, SHBG, anti-müllerian-hormone, androstenedione, dehydroepiandrosterone sulphate, progesterone, oestradiol (sensitive method for postmenopausal women), LH and FSH, at baseline, 12 and 52 weeks postoperatively

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures