Evaluation of pattern of behaviour in subtypes of Parkinsons Disease in response to non-invasive brain stimulation - TMS-PD

ICMR Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia);
•2.PWP of both gender with H&Y stage from 1 to 2.5
•3.PWP between age 45 to 75 on stable medication for at least 30 days.
•4.Controls: Healthy adults of both gender aged 45-60

•1.Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes;
•2.History of ICSOL (intracranial space occupying lesion) or brain surgeries, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length;
•3.Family (1st degree relatives) history of epilepsy;
•4.Presence of contraindications for functional magnetic resonance imaging (fMRI) like metal implants, and claustrophobia;
•5.History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year;
•6.Need for rapid clinical response due to conditions such as psychosis, or suicide tendency;
•7.PWP with uncontrolled hypertension and diabetes and other uncontrolled medical illness. PWP with hypertension or diabetes would be included only if they are stable on medication for last six months.

发起方

ICMR Delhi