NL-OMON48291已完成不适用
The interaction of Cognitive Control Mechanisms and Language Processing: An Investigation with Methylphenidate - Cognitive Control & Language
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Healthy volunteers between 18 and 45 years old;
- •Native Dutch speakers.
- •Right-handed
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •(History of) psychiatric treatment;
- •(History of) psychosis or mania;
- •(History of) neurological diseases (e.g. Parkinson, epilepsie);
- •(History of) neurological treatment;
- •(History of) endocrine treatment;
- •(History of) cardiac or vascular diseases;
- •(History of) blood illness (e.g. anemia, porphyria);
- •(History of) endocrine / metabolic disease;
- •(History of) of stomach or gastrointestinal tract disease;
- •(History of) vasovagale reflex syncope;
- •Experience of irregular sleep-wake rhythm;
- •(History of) obstructive respiratory disease
- •(History of) frequent autonomic failure (e.g. vasovagal reflex syncope);
- •(History of) clinically significant renal or hepatic disease;
- •(History of) epilepsy in adulthood (i.e. no insult after 18 years of age, no current medication for epilepsy, and no insult in the last five years);
- •(History of) glaucoma;
- •(History of) drug addication (e.g. opiate, (meth)amphetamine, lysergic acid diethylamide, cocaine, solvents or barbiturate) or alcohol dependence;
- •One first degree or two or more second degree family members with a history of sudden death or ventricular arrhythmia;
- •Problems slicking or problems with the esophagus ();
- •Frequent experience of headrush (vertigo);
- •Past or current treatment of hyperthyroidism;
- •Current experience of an acute infection (e.g. fever);
- •First degree family member with schizophrenia or bipolar disorder;
- •Abnormal hearing or (uncorrected) vision;
- •Use of psychotropic medication or recreational drugs weekly or more over a period of more than three months in the last 6 months;
- •Use of drug within 2 weeks prior to the start of the study;
- •Use of alcohol within the last 24 hours before each test session;
- •Dependence on cannabis or weekly cannabis usage for the last 6 months;
- •Strong smoking behaviour starting at more than 1 package of cigarettes per week;
- •Hypersensitivity for e.g. beta blockers or methylphenidate;
- •Previous use of Methylphenidate (Ritalin);
- •Uncontrolled hypertension, defined as diastolic blood pressure at rest >95 mmHg or systolic blood pressure at rest >180 mmHg;
- •Irregular sleep/wake rhythm (e.g. regular nightshifts or cross timeline travel);
- •Possible pregnancy or breastfeeding;
- •Lactose intolerance (because the placebo pill will be a lactose product);
- •Language related disabilities (e.g. dyslexia, stuttering);
- •Daily intense physical training.
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