Impact of Lung Recruitment Maneuvers and Positive End-Expiratory Pressure (PEEP) on Intracranial Pressure in Patients Undergoing Cranial Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intracranial Pressure Increase
- Sponsor
- University of Chile
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Subdural intracranial pressure (sICP) mmHg
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.
However, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.
Detailed Description
In general anesthesia for neurosurgery, mechanical ventilation is the standard approach. However, mechanical ventilation can induce pulmonary parenchymal injury through various mechanisms, including volutrauma, barotrauma, and atelectrauma. These correspond to lung damage caused by high tidal volumes, elevated airway pressures, repetitive alveolar collapse, and reopening. Protective ventilation strategies include limiting tidal volume (Vt), applying positive end-expiratory pressure (PEEP), and performing alveolar recruitment maneuvers (ARM). Historically, both ARM and higher levels of PEEP have been avoided in neurocritical patients, including those undergoing neurosurgery, due to concerns about their potential impact on intracranial pressure (ICP) and cerebral perfusion pressure (CPP). As postoperative pulmonary complications can significantly alter the prognosis of surgical patients, increasing hospital stay and healthcare costs, and, in neurocritical patients, compromising cerebral oxygenation, protective ventilation strategies may play a critical role in patients undergoing neurosurgery. Their historical exclusion from studies lacks demonstrated physiological justification. Here, the investigators aim to evaluate the impact of intrathoracic pressure on ICP in neurosurgical patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA classification I-III.
- •Elective cranial neurosurgery.
Exclusion Criteria
- •ASA classification IV or higher.
- •Documented intracranial hypertension.
- •Severe pulmonary disease (e.g., asthma, COPD).
- •Emergency surgery.
Outcomes
Primary Outcomes
Subdural intracranial pressure (sICP) mmHg
Time Frame: during the procedure
Change in sICP during an alveolar recruitment maneuver (ARM)
Secondary Outcomes
- Pulmonary mechanics parameters(Intraoperative)