Effect of ß3 agonist for treatment of ureteral stent-related symptoms
- Conditions
- Diseases of The genitoruinary system
- Registration Number
- KCT0003706
- Lead Sponsor
- Keimyung University Dongsan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 103
Adult patients(aged over 18 years men and women) who have ability to understand the ICF(informed consent form), willing and adhere to the consent specified in this protocol.
- Patients who underwent unilateral retrograde rigid ureteroscopic or flexible ureteroscopic
lithotripsy with planned ureteral stent insertion for kidney and ureter stone.
- Not signed informed consent form (ICF)
- Urogenital cancer that currently requires treatment
- Underwent bilateral ureteroscopic surgery;
- Serious comorbidity (infection, immunocompromised state, renal failure, cardiovascular disease, liver complaint, nerve disorder and mental illness)
- Severe coronary and cerebrovascular disease
- Acquired or congenital QT prolongation state
- Patient who taking CYP3A inhibitor
- Severe liver disease (2 times higher than normal level)
- Severe renal disease (GFR 15~29mL/min/1.73m2)
- Presence of uncontrolled hypertension (persistent systolic blood pressure [BP] =180mmHg or diastolic BP =110 mmHg).
- Patient who taking ß3 agonist, anticholinergics, steroid, Calcium Channel Blockers, analgesic or a-blockers.
- During pregnancy or lactation.
- Ureteropathy like ureteral stricture.
- Patient who contraindicated taking ß3 agonist and anticholinergics
- History of pelvic surgery or irradiation
- History of bladder or prostate surgery
- History of percutaneous, laparoscopic, robotic or open urinary stone surgery
- Neurogenic bladder or overactive bladder
- Patient who inadequate participation in the study at the discretion of the investigator
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SSQ (Body pain subscore)
- Secondary Outcome Measures
Name Time Method SSQ (Urinary symptoms subscore);USSQ (General health subscore);USSQ (Work performance subscore);USSQ (Sexual matters subscore);USSQ (Additional problems subscore);IPSS questionnaire;Uroflowmetry/Residual urine (UFM/PVR);Medication compliance and side effects