Protective Ventilation Strategy During One-lung Ventilation: Effect on Postoperative Pulmonary Complications
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 87
- Locations
- 1
- Primary Endpoint
- postoperative pulmonary complications
Study Overview
Brief Summary
The purpose of this study is to find a proper ventilation strategy for one-lung ventilation to prevent postoperative pulmonary complications
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients undergoing elective thoracic surgery
- •ASA I, II, III
- •scheduled > 2 hours of surgery
Exclusion Criteria
- •denied patients
- •age under 18 years
- •FEV1/FVC or FEV1<70% in preoperative pulmonary function test
Arms & Interventions
conventional tidal group
provide tidal volume of 6ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
Intervention: ventilator setting during one-lung ventilation (Other)
low tidal group
provide tidal volume of 4ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
Intervention: ventilator setting during one-lung ventilation (Other)
high tidal group
provide tidal volume of 8ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
Intervention: ventilator setting during one-lung ventilation (Other)
Outcomes
Primary Outcomes
postoperative pulmonary complications
Time Frame: immediately after operation
PaO2/FiO2 and/or newly appeared atelectasis, lung infiltration
Secondary Outcomes
No secondary outcomes reported
Investigators
Jae-Hyon Bahk, MD, PhD
Professor
Seoul National University Hospital