Brain and Mindfulness
- Conditions
- Healthy
- Interventions
- Other: Magneto-encephalography (MEG)Other: Electro-encephalography (EEG)Other: Functional Magnetic Resonance Imaging (fMRI)Other: Anatomical Magnetic Resonance Imaging (aMRI)Other: Meditation
- Registration Number
- NCT03117478
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 169
- Age : 25-70
- Being affiliated to a social security system.
- Motivated to participate in this study.
- Medication acting on the central nervous system
- Opioids, Antidepressive Agents.
- Actual or previous neurological or psychiatric illnesses
- Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
- Not having a personal or family history of epilepsy
- Alcohol or drugs consumption 2 days before or during the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1. Participants without meditation experience Anatomical Magnetic Resonance Imaging (aMRI) Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 2. Participant with a significant meditation experience Electro-encephalography (EEG) Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 4. Participant with a significant meditation experience Magneto-encephalography (MEG) Experts : \> 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 4. Participant with a significant meditation experience Electro-encephalography (EEG) Experts : \> 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 1. Participants without meditation experience Electro-encephalography (EEG) Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 1. Participants without meditation experience Functional Magnetic Resonance Imaging (fMRI) Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 3. Participants without meditation experience Electro-encephalography (EEG) Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 3. Participants without meditation experience Functional Magnetic Resonance Imaging (fMRI) Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 1. Participants without meditation experience Magneto-encephalography (MEG) Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 1. Participants without meditation experience Meditation Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 2. Participant with a significant meditation experience Magneto-encephalography (MEG) Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 2. Participant with a significant meditation experience Anatomical Magnetic Resonance Imaging (aMRI) Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 2. Participant with a significant meditation experience Meditation Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 2. Participant with a significant meditation experience Functional Magnetic Resonance Imaging (fMRI) Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. 3. Participants without meditation experience Magneto-encephalography (MEG) Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 3. Participants without meditation experience Anatomical Magnetic Resonance Imaging (aMRI) Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 4. Participant with a significant meditation experience Functional Magnetic Resonance Imaging (fMRI) Experts : \> 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). 4. Participant with a significant meditation experience Anatomical Magnetic Resonance Imaging (aMRI) Experts : \> 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
- Primary Outcome Measures
Name Time Method Anatomical MRI scan Day 1 Brain structure
Functional MRI scan Day1 Brain activation: Haemodynamic response - BOLD signal.
EEG Day 1 Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz
- Secondary Outcome Measures
Name Time Method Behavioral measure : Accuracy of the performed task actions Day 1 Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits
Psychophysics: Pain threshold Day 1 Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.
Psychophysiology : Respiration Day 1 Respiration rate: breaths/minute
Subjective experience of the participant Day 1 Studies biomarkers of inflammation Day 1 area of the inflamed site in mm\^2, obtained by automatic image processing of a photography
Behavioral measure : Speed of the performed task actions Day 1 Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms.
Psychophysiology : Heart Day 1 Heart Rate: pulses/minute
Psychophysiology : Heart rate variability Day 1 Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms.
Psychophysiology : Muscles Day 1 Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV.
Psychophysiology : Eyes Day 1 Eye gaze position: relative to center of the screen, in imm
Psychophysiology : Pupillar response Day 1 Pupillar response: pupil diameter, in mm.
Electrogastrogram Day 1 Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute)
Trial Locations
- Locations (1)
Le Vinatier
🇫🇷Bron, France