Brain and Mindfulness
- Conditions
- Healthy
- Registration Number
- NCT03117478
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 169
- Age : 25-70
- Being affiliated to a social security system.
- Motivated to participate in this study.
- Medication acting on the central nervous system
- Opioids, Antidepressive Agents.
- Actual or previous neurological or psychiatric illnesses
- Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
- Not having a personal or family history of epilepsy
- Alcohol or drugs consumption 2 days before or during the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Anatomical MRI scan Day 1 Brain structure
Functional MRI scan Day1 Brain activation: Haemodynamic response - BOLD signal.
EEG Day 1 Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz
- Secondary Outcome Measures
Name Time Method Behavioral measure : Accuracy of the performed task actions Day 1 Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits
Psychophysics: Pain threshold Day 1 Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.
Psychophysiology : Respiration Day 1 Respiration rate: breaths/minute
Subjective experience of the participant Day 1 Studies biomarkers of inflammation Day 1 area of the inflamed site in mm\^2, obtained by automatic image processing of a photography
Behavioral measure : Speed of the performed task actions Day 1 Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms.
Psychophysiology : Heart Day 1 Heart Rate: pulses/minute
Psychophysiology : Heart rate variability Day 1 Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms.
Psychophysiology : Muscles Day 1 Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV.
Psychophysiology : Eyes Day 1 Eye gaze position: relative to center of the screen, in imm
Psychophysiology : Pupillar response Day 1 Pupillar response: pupil diameter, in mm.
Electrogastrogram Day 1 Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute)
Trial Locations
- Locations (1)
Le Vinatier
🇫🇷Bron, France
Le Vinatier🇫🇷Bron, France