The Impact of Meditation Practice on Attention and Emotion Regulation :Studies on Neural Correlation in Brain Imagery and Biomarkers of Stress and Inflammation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 169
- Locations
- 1
- Primary Endpoint
- Anatomical MRI scan
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age : 25-70
- •Being affiliated to a social security system.
- •Motivated to participate in this study.
Exclusion Criteria
- •Medication acting on the central nervous system
- •Opioids, Antidepressive Agents.
- •Actual or previous neurological or psychiatric illnesses
- •Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
- •Not having a personal or family history of epilepsy
- •Alcohol or drugs consumption 2 days before or during the study.
Outcomes
Primary Outcomes
Anatomical MRI scan
Time Frame: Day 1
Brain structure
Functional MRI scan
Time Frame: Day1
Brain activation: Haemodynamic response - BOLD signal.
EEG
Time Frame: Day 1
Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz
Secondary Outcomes
- Behavioral measure : Accuracy of the performed task actions(Day 1)
- Psychophysics: Pain threshold(Day 1)
- Psychophysiology : Respiration(Day 1)
- Subjective experience of the participant(Day 1)
- Studies biomarkers of inflammation(Day 1)
- Behavioral measure : Speed of the performed task actions(Day 1)
- Psychophysiology : Heart(Day 1)
- Psychophysiology : Heart rate variability(Day 1)
- Psychophysiology : Muscles(Day 1)
- Psychophysiology : Eyes(Day 1)
- Psychophysiology : Pupillar response(Day 1)
- Electrogastrogram(Day 1)