The Impact of Meditation Practice on Attention and Emotion Regulation :Studies on Neural Correlation in Brain Imagery and Biomarkers of Stress and Inflammation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 169
- Locations
- 2
- Primary Endpoint
- Functional MRI scan
Study Overview
Brief Summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 25 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age : 25-70
- •Being affiliated to a social security system.
- •Motivated to participate in this study.
Exclusion Criteria
- •Medication acting on the central nervous system
- •Opioids, Antidepressive Agents.
- •Actual or previous neurological or psychiatric illnesses
- •Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
- •Not having a personal or family history of epilepsy
- •Alcohol or drugs consumption 2 days before or during the study.
Arms & Interventions
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Magneto-encephalography (MEG) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Electro-encephalography (EEG) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Functional Magnetic Resonance Imaging (fMRI) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Meditation (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Magneto-encephalography (MEG) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Electro-encephalography (EEG) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Functional Magnetic Resonance Imaging (fMRI) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
Intervention: Meditation (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Magneto-encephalography (MEG) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Electro-encephalography (EEG) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Functional Magnetic Resonance Imaging (fMRI) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Magneto-encephalography (MEG) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Electro-encephalography (EEG) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Functional Magnetic Resonance Imaging (fMRI) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
Intervention: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
Outcomes
Primary Outcomes
Functional MRI scan
Time Frame: Day1
Brain activation: Haemodynamic response - BOLD signal.
EEG
Time Frame: Day 1
Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz
Anatomical MRI scan
Time Frame: Day 1
Brain structure
Secondary Outcomes
- Electrogastrogram(Day 1)
- Behavioral measure : Accuracy of the performed task actions(Day 1)
- Psychophysics: Pain threshold(Day 1)
- Psychophysiology : Respiration(Day 1)
- Subjective experience of the participant(Day 1)
- Studies biomarkers of inflammation(Day 1)
- Behavioral measure : Speed of the performed task actions(Day 1)
- Psychophysiology : Heart(Day 1)
- Psychophysiology : Heart rate variability(Day 1)
- Psychophysiology : Muscles(Day 1)
- Psychophysiology : Eyes(Day 1)
- Psychophysiology : Pupillar response(Day 1)