The Association Between Chlorhexidine Bathing and Central Line-Associated Infections in Medical Intensive Care Units

Completed

• Conditions: Central Line-associated Bloodstream Infection (CLABSI)
• Interventions: Other: Chlorhexidine bathing

• Registration Number: NCT05919966
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

We conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% CHG wipes every other day and the occurrence of central line-associated infections (CLABSI) in patients within the medical intensive care unit (MICU).

Detailed Description

This study defined the post-intervention period as July 1, 2017, to June 30, 2022. During this period, one of the three medical intensive care units (MICUs) in NTUH implemented chlorhexidine gluconate (CHG) bathing as part of their daily care routine (CHG group). This decision was made in response to a higher incidence rate of vancomycin-resistant Enterococcus (VRE) bacteremia observed in that particular MICU during the preceding six months (pre-intervention period: January 1, 2017, to June 30, 2017), compared to the other two MICUs. The remaining two MICUs continued to provide usual care, which involved bathing patients with towels soaked in water and soap on a daily basis.

Study Timeline

• Status Verified: 2023-04
• Study Start: 2023-04-12
• Primary Completion: 2023-04-30
• Study Completion: 2023-05-30
• Study First Submitted: 2023-06-13
• Study First Submitted QC: 2023-06-25
• Last Update Submitted: 2023-06-25
• Study First Posted: 2023-06-27
• Last Update Posted: 2023-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6930

Inclusion Criteria

• all patients who were admitted to the MICU between January 2017 and June 2022

Exclusion Criteria

• patients aged under 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
chlorhexidine group	Chlorhexidine bathing	Patients were bathed one day involving the use of wipes soaked in a 2% chlorhexidine gluconate (CHG) solution and the next day using a towel soaked with water and soap during the MICU stays.

Primary Outcome Measures

Name	Time	Method
central line-associated bloodstream infections	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	the incidence rate of intensive care unit acquired central line-associated bloodstream infections
multidrug-resistant organisms bacteremia	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	the incidence of CLABSIs with blood cultures positive for multidrug-resistant organisms

Secondary Outcome Measures

Name	Time	Method
ICU length of stay	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	the total duration of the patient's ICU stay (days)
ICU mortality	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	whether the patient has died during their stay in the ICU
hospital length of stay	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	the total duration of the patient's hospital stay (days)
hospital mortality	Will be surveyed retrospectively through the study period (January 2017 to June 2022)	whether the patient has died during their stay in the hospital

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan