Efficacy Study of Rapid Test to Prevent Hospital Transmission of Methicillin-Resistant Staphylococcus Aureus (MRSA)
- Conditions
- Methicillin ResistanceStaphylococcus AureusStaphylococcal Infection
- Interventions
- Other: Rapid MRSA PCR test for screening carriers
- Registration Number
- NCT00846105
- Lead Sponsor
- Erasme University Hospital
- Brief Summary
The purpose of this study is to evaluate the efficacy of a novel PCR-based laboratory test for rapid detection of MRSA carriers to prevent transmission of MRSA in the Belgian acute care hospital setting.
- Detailed Description
Methicillin-resistant Staphylococcus aureus (MRSA) strains have become endemic pathogens in acute and chronic healthcare facilities in Belgium. MRSA infection is causing increased public concern as it carries a significant risk of morbidity, mortality and has been linked to substantial excess healthcare costs.
Efficient control of MRSA transmission within healthcare facilities critically depends on screening for and isolation of MRSA carriers among admitted patients. Active surveillance cultures for MRSA are now part of clinical practice recommendations both in Europe and the USA. Indeed, studies have indicated that up to 70 % of the patient reservoir for MRSA among hospitalized patients can only be detected by active sampling of muco-cutaneous colonization sites. There is an urgent public health need for early and reliable detection of carriers of MRSA among patients admitted to healthcare facilities, to inform patient isolation and decontamination procedures, and thereby more effectively control cross-infection
The general objectives of this intervention study to be conducted in two large Belgian hospitals are to measure the impact of rapid (\< 3 h) PCR detection of MRSA carriage upon patient admission on shortening the delay to implement contact isolation precautions for carriers and reducing nosocomial MRSA transmission to patients admitted in the same wards.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7400
-
All patients admitted for more than 48h to a ward in which evaluation in the previous baseline period met the following:
- > 80 % compliance with admission and discharge conventional culture screening, for the pooled admissions to all study wards;
- > 80 % compliance with additional MRSA contact isolation procedures, based on a sample of 50 patient care contact observations per hospital in all study wards;
- pooled incidence of nosocomial MRSA acquisition ≥ 1.5 new cases /100 at risk admissions in the study wards.
- Patients staying 48h or less in the study wards
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Rapid PCR screen Rapid MRSA PCR test for screening carriers Rapid PCR screen test for detection of MRSA carriers upon hospital admission Conventional culture Rapid MRSA PCR test for screening carriers Conventional culture screen for detection of MRSA carriers upon hospital admission
- Primary Outcome Measures
Name Time Method To determine if a ≥ 50 % reduction of incidence of nosocomial MRSA acquisition can be observed after replacing culture by PCR for universal MRSA screening of patients upon admission to high incidence units in two acute care hospitals 5-10 months
- Secondary Outcome Measures
Name Time Method Median time required for detection of MRSA carriage after admission 5-10 months Median time required for starting isolation of MRSA carriers 5-10 months Number of patient-days of MRSA carrier stay in non-isolated conditions 5-10 months MRSA nosocomial infection rate 5-10 months MRSA cross-transmission rate 5-10 months Sensitivity and specificity of PCR vs conventional MRSA screening by culture 10 months
Trial Locations
- Locations (2)
ULB Hopital Erasme
🇧🇪Brussels, Belgium
Algemeen Ziekenhuis Sint-Jan AV
🇧🇪Brugge, Belgium