The role of receptor for advanced glycation end products (RAGE’s) and soluble RAGE (sRAGE) in Coronary Artery Disease patients with Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Serum levels of RAGE and sRAGE in Coronary artery disease patients with and without diabetes mellitus
研究概览
简要总结
Coronary artery disease and Myocardial Infarction is one of the major cause of premature death worldwide
advanced glycation end products is known to be a factor in increasing and starting atherosclerosis in patients of Diabetes Mellitus leading to Myocardial Infarction. Activation of Receptor for Advanced glycation end products (RAGE) is also being considered as a factor for worsening Atherosclerosis
By this study we are trying to corelate the Levels and expression of RAGE gene in patients with and without diabetes mellitus and levels of atherosclerosis in patients with CAD
The study is divided into 2 groups .Group 1 consists of 80 Patients with angiographically proven Coronary Artery disease (CAD) with Diabetes Mellitus and group 2 consists of 80 Patients with CAD without diabetes mellitus . The study is going to be conducted in GIPMER delhi
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with confirmed cases of Atherosclerosis with Coronary Angiography with more than 50% stenosis in atleast one vessel.
排除标准
- •Patients with Acute Coronary Syndrome such as Myocardial Infarction and Patients with Cardiac diseases such as Valvular diseases and Cardiomyopathy.
结局指标
主要结局
Serum levels of RAGE and sRAGE in Coronary artery disease patients with and without diabetes mellitus
时间窗: 1 YEAR
次要结局
- RAGE gene expression and its correlation with blood levels of RAGE and sRAGE and patient phenotype in above patient groups(1 year)
研究者
Dr Mohit Singh
GB Pant Hospital, GIPMER