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Clinical Trials/NCT02650440
NCT02650440
Completed
N/A

Robot-assisted Locomotor Training After Severe Stroke: Discrete Versus Rhythmic Movement

Thais Amanda Rodrigues1 site in 1 country20 target enrollmentNovember 2014

Overview

Phase
N/A
Intervention
Not specified
Conditions
Stroke
Sponsor
Thais Amanda Rodrigues
Enrollment
20
Locations
1
Primary Endpoint
Functional Ambulation Scale (FAC)
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

The objective of this study is to compare the effects of novel versus standard locomotor training using a robotic gait orthosis (LT-RGO) after stroke. The hypothesis is that the novel LT-RGO protocol, by establishing a progressive decrease in gait velocity and guidance force, may facilitate greater motor recovery compared to the use of a standard protocol.

Detailed Description

Standard (rhythmic) robot-assisted locomotor training on a bodyweight-supported treadmill (LT-BWST) used progressively increased speed each week. Novel (discrete) robot-assisted LT-BWST used progressive decrease in speed. The novel approach of slowing down the treadmill reduced momentum. If speed had been increased (standard approach), momentum would have increased (momentum = mass \* velocity); and the resulting, passive propulsion of momentum would have diminished the role of cortical skills needed to plan, initiate, and overtly control gait. In sum, the novel protocol used a slower-than-standard treadmill speed in order to provide a window of time sufficient for the corticomotor system to process information, learn, and adjust its response to internal and external feedback (eg, proprioceptive input; therapist input) during robot-assisted LT-BWST.

Registry
clinicaltrials.gov
Start Date
November 2014
End Date
September 2016
Last Updated
8 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Thais Amanda Rodrigues
Responsible Party
Sponsor Investigator
Principal Investigator

Thais Amanda Rodrigues

Physiotherapist

University of Sao Paulo

Eligibility Criteria

Inclusion Criteria

  • Clinical diagnosis of stroke and image with hemiparesis left or right;
  • No more that one ischemic or hemorrhagic stroke episode;
  • 06 months post-stroke;
  • Verified clinical stability on medical evaluation;
  • Spasticity level I or II in the Ashworth scale;
  • Score 1-2 in the Functional Ambulation Scale (FAC);
  • Signed informed consent.

Exclusion Criteria

  • Dependence to perform activities of daily living before the stroke;
  • Lack of clinical indications for exercises (such as cardiopulmonary instability and uncontrolled diabetes);
  • Severe cognitive impairment;
  • Serious psychiatric change that needs psychiatric care;
  • Severe osteoporosis;
  • Severe spasticity of the lower limbs, deformities or fixed contractures that prevent the achievement of movements;
  • Lack of resistance or disabling fatigue;
  • Body weight greater than 150 kg;
  • Unstable angina or other untreated heart disease;
  • Chronic obstructive pulmonary disease;

Outcomes

Primary Outcomes

Functional Ambulation Scale (FAC)

Time Frame: Baseline and 6 weeks

The Functional Ambulation Scale (FAC) assesses an individual's independence during gait and follows a six-level scale: 0 - Patient can not walk or ask for help from two or more people; 1 - Patient requires continuous support from a person who assists with weight and balance; 2 - Patient needs continuous or intermittent support from a person to help with balance and coordination; 3 - Patient required for a person without physical contact; 4 - Patient can walk independently on the floor, but requires help on stairs and ramps; 5 - Patient can walk independently. This study compared the gait independence by the FAC between the two Arms, after intervention as compared to baseline.

Secondary Outcomes

  • Time Up and Go (TUG)(Baseline and 6 weeks)
  • Ten-meters Walking Test (10MWT)(Baseline and 6 weeks)
  • Six-minute Walking Test (6MWT)(Baseline and 6 weeks)
  • Lower Limbs Fugl-Meyer(Baseline and 6 weeks)
  • Berg Scale(Baseline and 6 weeks)

Study Sites (1)

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