The Effects of PaCO2 Levels on Cerebral Metabolism and Perfusion During Induced Hypothermia.

Not Applicable

Completed

• Conditions: Cerebral Metabolism and Perfusion
• Interventions: Other: mild hypo- and hyperventilation

• Registration Number: NCT00766103
• Lead Sponsor: Tampere University Hospital

Brief Summary

Incidence of hypo- and hypercarbia during induced hypothermia after cardiac arrest is high. The original report from HACA-group reported that hypothermia treated patients had improved survival and neurological outcome. Suprisingly, in that trial normocarbia was not achieved even though the aim was set for ventilatory support as normoventilation. This study aims to investigate the effects of mild hypo- and hypercarbia on cerebral perfusion (blood flow, intracranial pressure) and metabolism (microdialysate metabolites). We hypothesize that uncontrolled ventilatory suppport may render the patients in risk of exacerbation of neuronal damage, conversely, further improvement in outcome may be achieved with succesfull ventilatory management. We intend to enroll 10 out-of-hospital cardiac arrest patients succesfully resuscitated and subsequently treated with controlled hypothermia for 24 hours. The patients in need of anticoagulation are excluded. We plan to induce mild hypocarbia and hypercarbia during and after induced hypothermia. Metabolic and perfusion data are collected with clinically used methods such as transcranial doppler, intracranial pressure measurement, near infrared spectroscopy, jugular bulb, intracerebral microdialysis).

Detailed Description

Not available

Study Timeline

• Study Start: 2006-12
• Primary Completion: 2008-05
• Study Completion: 2008-05
• Study First Submitted: 2008-10-02
• Study First Submitted QC: 2008-10-02
• Study First Posted: 2008-10-03
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-19
• Last Update Posted: 2016-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

succesfull resuscitation of out of hospital cardiac arrest, primary rhytm shockable

Exclusion Criteria

• known coagulopathy, need of anticoagulation therapy, need of interventional cardiological procedures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
crossover: hypo- and hypercarbia	mild hypo- and hyperventilation	-

Primary Outcome Measures

Name	Time	Method
surrogate physiological endpoints	60minutes

Trial Locations

Locations (1)

Critical Care Medicine Research Group/ department of intensive care; 🇫🇮 Tampere, Pirkanmaa, Finland