Evaluation of Procalcitonin and C-Reactive Protein as a prognostic marker among Sepsis patients in Oncology ICU
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 153
- Locations
- 2
- Primary Endpoint
- Mortality at Day 28 from the inclusion of study
Study Overview
Brief Summary
Adult patients admitted in oncology ICU aged > 18 will be screened for sepsis as SOFA score > 2. The Primary objectiveis to evaluate PCT and CRP as a marker in predicting mortality among sepsis patients in oncology ICU ; our Secondary objective is to assess the correlation of PCT and CRP with SOFA score in predicting severity of disease. and to assess the correlation of PCT and CRP with length of ICU stay. PCT, CRP will be measured on Day 0, 2 and 4. Patients will be followed up for a mortality, duration of ICU stay and recovery. At 28 th day patient/ patient’s attender will be called telephonically to assess for mortality or recovery. The discriminant performance of Day 0, 2, and 4 values of CRP and PCT in predicting within 28-day mortality will be assessed using the ROC curve analysis. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) will be calculated.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 69.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Sequential organ failure assessment score more than or equal to 2.
Exclusion Criteria
- •1.Refusal for participation in the study 2.Autoimmune diseases 3.Postoperative patients (upto postoperative day 3) 3.Recent Myocardial Infection 4.Pregnant patients.
Outcomes
Primary Outcomes
Mortality at Day 28 from the inclusion of study
Time Frame: Mortality at 28 th day from the inclusion of study
Secondary Outcomes
- Duration of ICU stay from the day of inclusion in the study to discharge/death(SOFA score at Day 0 ,2 & 4 from the day of inclusion in the study)
Investigators
Subalakshmi
All India Institute of Medical Sciences,New Delhi