Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 3
- 主要终点
- Dilantin levels
研究概览
简要总结
It is unclear how enteral nutrition via a feeding tube should be given when a patient is receiving enteral Dilantin. Some caregivers hold the feedings for one hour before and one hour after the Dilantin dose to insure adequate absorption of the medication and some caregivers think that the feedings do not need to be interrupted.
Hypothesis: Dilantin levels will remain therapeutic when enteral nutrition is given continuously during the administration of enteral Dilantin.
The objective of this study is to determine Dilantin levels when enteral feedings are given by the continuous method. Thirty patients will be studied. When Dilantin levels are in the therapeutic range for 2 consecutive days on interrupted feedings (baseline), the patient will be switched to continuous feedings uninterrupted for the medication, for 7 days. Dilantin levels will be checked daily and if the levels become subtherapeutic an intravenous (IV) bolus of Dilantin will be given and the enteral dose will be increased (doses determined by primary caregiver). Serum albumin will be measured at baseline and at the beginning and end of each week, in order to calculate free Dilantin.
详细描述
Rationale: It is unclear how enteral nutrition via feeding tube should be given when a patient is receiving enteral Dilantin. Some caregivers hold the feedings for one hour before and one hour after the Dilantin dose to insure adequate absorption of the medication and some caregivers think that the feedings do not need to be interrupted. Both methods are used in this institution, although the interrupted method is recommended by the Clinical Nutrition Service. Interrupting the feedings has the obvious disadvantage that the patient receives less hours of feeding and requires more nursing intervention.
Key Objectives: To determine the change in Dilantin levels when enteral feedings are given by the continuous method.
Study Population: 30 patients already on Dilantin for seizure prophylaxis who are already receiving enteral nutrition by the interrupted method and have stable, therapeutic Dilantin levels.
Major Inclusion Criteria:
- on Dilantin for seizure prophylaxis (dose determined by primary caregiver) with therapeutic Dilantin levels
- receiving enteral nutrition by the interrupted method at goal feeding rate;
- age >18
- feeding tube in proper position, no restriction as to type of feeding tube (nasogastric, nasoduodenal, gastrostomy, jejunostomy), but both Dilantin and enteral feeding must be given through the same tube.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •On Dilantin for seizure prophylaxis (dose determined by primary caregiver) with therapeutic Dilantin levels
- •Receiving enteral nutrition by the interrupted method at goal feeding rate
- •Feeding tube in proper position, no restriction as to type of feeding tube (nasogastric, nasoduodenal, gastrostomy, jejunostomy), but both Dilantin and enteral feeding must be given through the same tube
排除标准
- •History of seizures
- •Albumin infusions necessary during study period
- •Anticipation that feedings will need to be held for more than 4 hours at a time
- •Patients that do not maintain stable Dilantin levels (< 25% variability) with the interrupted method of feeding
- •Inability to obtain consent from patient or spokesperson
结局指标
主要结局
Dilantin levels
次要结局
未报告次要终点