Value of CMR Including T1 Mapping in Patients With Acute Myocarditis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- T1 relaxation times
研究概览
简要总结
To evaluate the additive values of T1 mapping in patients with acute myocarditis.
详细描述
Cardiac magnetic resonance (CMR) is an established non-invasive diagnostic tool for acute and chronic myocarditis. Established CMR criteria for diagnosing myocarditis are edema on black-blood T2-weighted imaging, relative contrast enhancement seen on T1-weighted imaging for assessment of hyperemia, and late contrast-agent enhancement seen with inversion recovery late enhancement technique for visualization of myocardial fibrosis.
Recently, tissue characterization based on calculation of myocardial T1 relaxation time (T1 mapping) as well as T1-derived extracellular volume fraction has become available. Recently, reference values for myocardial T1 relaxation times at 3T for healthy volunteers were published for CMR. However, to date no comprehensive data for multiparametric CMR in patients with suspected myocarditis at 3 Tesla is available. Therefore, the purpose of this prospective study was to evaluate the diagnostic value of CMR at 3T in patients with suspected acute myocarditis using a multiparametric CMR approach including T1 mapping as novel tool for tissue characterization.
CMR will be performed within 7 days after hospital admission for "suspected acute myocarditis".
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with suspected acute myocarditis and otherwise unremarkable cardiac history
排除标准
- •exclusion of CAD in invasive coronary angiography
- •pregnancy
- •contraindications for MR imaging
结局指标
主要结局
T1 relaxation times
时间窗: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis".
quantification of T1 relaxation times
次要结局
- Extracellular volume (ECV)(time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis".)
研究者
Claas P. Naehle
section chief cardicvascular imaging
University Hospital, Bonn