The Anemia Control Program: Early Intervention
- Conditions
- Iron Deficiency Anemia
- Registration Number
- NCT00998998
- Lead Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Brief Summary
The purpose of this study was to determine if a home-based intervention to foster child development improved behavior and development in infants with IDA.
- Detailed Description
Iron-deficiency anemia (IDA) is associated with alterations in infant behavior and development that may not correct with iron therapy. The purpose of this study was to determine if a home-based intervention to foster child development improved behavior and development in infants with IDA. IDA and non-anemic infants were randomly assigned to a year of intervention or surveillance only. Infants were enrolled and began study participation at 6 or 12 months. All infants were treated with oral iron and visited weekly to record iron intake, feeding, and health (surveillance). For infants randomized to intervention, the weekly home visit included an hour-long program fostering child development by supporting the mother-infant relationship. Psychologists, unaware of iron status or intervention assignment, assessed cognitive, motor, and social-emotional development (Bayley Scales) at the beginning, midpoint, and end of the year.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 277
- birth weight >= 3.0kg
- singleton full-term birth
- routine vaginal delivery
- no major congenital anomalies
- no major perinatal complications
- no photo therapy
- no hospitalization for longer than 5 days
- no chronic illness
- no iron therapy
- from 1991-94, infants on >= 250 ml/day cow milk or formula
- from 1994-96, infants could be on < 250 ml/day cow milk or formula
- infants identified as anemic at 6 or 12 months and randomly selected nonanemic infants at 6 and 12 months
- residence outside 4 contiguous working-class communities on outskirts of Santiago, Chile
- another infant <12 months in household
- infant in child care
- illiterate or psychotic caregiver or no stable caregiver available to accompany the child for appointments.
- until mid-1994, "exclusive" breastfeeding, defined as >250 mL/d cow milk or formula
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Infant behavior and development 6, 12, and 18 months; or 12, 18, and 24 months
- Secondary Outcome Measures
Name Time Method Iron-deficiency anemia 6, 12, and 18 months; or 12, 18 and 24 months
Trial Locations
- Locations (1)
Instituto de Nutrición y Tecnología de los Alimentos (INTA)
🇨🇱Santiago, Chile
Instituto de Nutrición y Tecnología de los Alimentos (INTA)🇨🇱Santiago, Chile