Comparative evaluation of the effect of cryotherapy, low level laser therapy and intraligamentary injection of dexamethasone on the onset and severity of post-treatment pain after single visit root canal treatment - a randomized controlled trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To assess post-operative pain using Visual Analogue Scale
研究概览
简要总结
This study is a randomized, triple blind (patient,outcome assessor and data analyst), parallel group, placebo controlled trial which aims to compare and evaluate the efficacy of 3 modes of adjunctive therapies (namely cryotherapy, low level laser therapy and intraligamentary injection of dexamethasone) on onset and severity of post treatment pain after single-visit root canal treatment.
According to previously published data, frequency of post operative endodontic pain ranges from 1.4 to 16% and sometimes up to 50% in some studies.The strategies recommended to prevent endodontic postoperative pain can be categorized as pharmacologic or nonpharmacologic.
Cryotherapy affects the conduction capacity of nociceptors and activates thermoreceptors thereby blocking nociception within the spiral cord. In dentistry, cold application has been frequently utilised following intraoral surgical procedures for postoperative pain control.
Studies have shown that supra periosteal infiltration or intraligamentary infiltration of dexamethasone can reduce or even prevent postoperative pain in patients.
Low level laser therapy or LLLT exerts neuron-regenerative and anti-inflammatory effects to provide pain control.
The most common and reliable method for evaluating the outcome of treatments is randomized controlled clinical trial (Elwood 1998), because of minimum confounders and maximum control over the trial environment.
Therefore, this randomized controlled trial will be done to evaluate and compare the effect of 3 modes of adjunctive therapies (namely cryotherapy, low level laser therapy and intraligamentary injection of dexamethasone) on onset and severity of post treatment pain after single-visit root canal treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with moderate to severe pain in mandibular molars and a diagnosis of symptomatic apical periodontitis needing a primary endodontic procedure.
排除标准
- •patients with systematic or allergic reactions, root canal retreatment, pregnancy, a history of medication within 3 days for chronic pain or those compromising the immune response , any contraindication or sensitivity to corticosteroids, failure to obtain authorization from patients, internal or external resorption, teeth with open apices, or any accident or complication occurring during treatment.
结局指标
主要结局
To assess post-operative pain using Visual Analogue Scale
时间窗: After 6,12,24,48 and 72 hours of treatment
次要结局
- Amount Of Analgesics used by the patients post operatively(After 6,12,24,48 and 72 hours of treatment)