Study to assess whether left atrial appendage ligation during coronary artery bypass grafting changes the incidence of stroke and atrial fibrillation in post operative period when compared to coronary artery bypass grafting without left atrial appendage ligatio
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients undergoing elective Coronary Artery Bypass Grafting
- Registration Number
- CTRI/2018/09/015571
- Lead Sponsor
- CNC AIIMS as a part of CABG package
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
All the adult patients undergoing on pump CABG at high predicted risk of POAF based on the CHA2DS2-VASC scoring system will be included in the study.
Exclusion Criteria
Patients with pacemaker in-situ H/o of Cox maze or radio-frequency ablation of atrial arrhythmia Moderate or severe Mitral Stenosis (MS) or Mitral Regurgitation(MR)
H/o of Myocardial Infarction in previous 3 months Incomplete pre-op diastolic function assessment Inability to document complete LAA ligation by intra-op TEE Pre-operative echocardiographic evidence of LAA clot
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.CABG with and without LAA ligation will be compared for incidence of clinical stroke. <br/ ><br>2. CABG with and without LAA ligation will be compared for incidence of clinically detectable atrial fibrillation, ECG detected atrial fibrillation <br/ ><br>3. All of the above comparison will be done at different time points of post-operative follow-up.Timepoint: 1. 1 week post operative <br/ ><br>2. 1 month post operative <br/ ><br>3. 3 months post operative <br/ ><br>4. 6 months post operative <br/ ><br>5. 12 months post operative <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method CABG with and without LAA ligation will be compared for incidence of clinically detectable atrial fibrillation, ECG and Holter detected atrial fibrillation and total time duration of atrial fibrillation on Holter. <br/ ><br>2. CABG with and without LAA ligation will also be compared for incidence of stroke. <br/ ><br>3. All of the above comparison will be done at different time points of post-operative follow-up.Timepoint: 1 week, 1 month, 3 momths, 6 months, 12 months