Comparative study of Hyperbaric Levobupivacaine (0.5%) with Dexmedetomidine given intrathecally versus Hyperbaric Levobupivacaine (0.5%) with Dexmedetomidine given intravenously in patients undergoing lower abdominal and lower limb surgeries under spinal anesthesia
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/05/052215
- Lead Sponsor
- ANAND S
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anesthesiologists (ASA) grade I-II.
-Age group between 18-65 years.
-Scheduled for Lower abdominal surgeries.
-Both Elective and Emergency procedures.
Exclusion Criteria
-Patient refusal
-Patients using alpha 2â??adrenergic receptors antagonists, calcium channel blockers, angiotensin â?? converting enzyme inhibitors
-History of allergy to study drugs
-Post spinal surgeries, Spinal Deformities
-Pregnancy
-Coagulopathy
-Dysrhythmia
-Major Hepatic, Renal and Cardiovascular Dysfunction
-BMI >35
-Height <140cm
-Heart Rate <60/min
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -To compare onset and duration of sensory blockade. <br/ ><br>-To compare onset and duration of motor blockade. <br/ ><br>Timepoint: Patient will be put in supine position soon after Sub arachnoid block motor and sensory blockade will assessed as baseline from the time of administration of test drug and each minute upto 15 minutes followed by every 15 minutes once upto 120 minutes
- Secondary Outcome Measures
Name Time Method To assess duration of analgesia.Timepoint: Duraion of analgesia will be noted (onset of sensory block to onset of pain postoperatively- VAS more than 3 <br/ ><br>;To assess Hemodynamic changes and side effects if anyTimepoint: Patientâ??s HR, NIBP, SPO2 will be monitored at 3 min interval up to 15 minutes after that every 5 mins up to 60 mins after that every 10 mins until end of the procedure.;To assess sedation scoreTimepoint: Ramsay Sedation score is monitored every 15 mins from the time of IV infusion for 2hrs intraoperatively and immediately at postoperative. <br/ ><br>