Nutritional Supplementation in Cognitive Aging

Not Applicable

Completed

• Conditions: Cognitive Aging
• Interventions: Dietary Supplement: whole fruit blueberry powder; Dietary Supplement: berry placebo powder; Dietary Supplement: blueberry juice; Dietary Supplement: Concord grape juice; Dietary Supplement: placebo juice

• Registration Number: NCT00599508
• Lead Sponsor: University of Cincinnati

Brief Summary

To evaluate the effect of supplemented berry fruit juice and whole fruit berry powder on memory performance and brain function in older adults

Detailed Description

Randomized trials involving daily supplementation with berry fruits in older adults with early memory changes. The berry products include Concord grape juice, blueberry juice, and whole fruit blueberry powder. Supplementation periods are 12 and 16 weeks, depending on berry product. The Aims of the studies are to assess effects on cognitive performance and in a subset of participants, in brain activity.

Study Timeline

• Study Start: 2006-06
• Study First Submitted: 2008-01-10
• Study First Submitted QC: 2008-01-10
• Study First Posted: 2008-01-23
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-07
• Last Update Posted: 2016-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Mild Cognitive Impairment

Exclusion Criteria

• Diabetes
• Weight of under 100 or over 210 pounds
• Chronic use of pain medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
blueberry powder intervention	whole fruit blueberry powder	whole fruit blueberry powder administered daily for 16 weeks
powder placebo	berry placebo powder	placebo powder administered daily for 16 weeks
blueberry juice active intervention	blueberry juice	wild blueberry juice administered daily for 12 weeks
grape juice active intervention	Concord grape juice	Concord grape juice administered daily for 12 or 16 weeks
juice placebo	placebo juice	berry placebo juice administered daily for 12 or 16 weeks

Primary Outcome Measures

Name	Time	Method
memory performance	at the end of the intervention

Secondary Outcome Measures

Name	Time	Method
cortisol	at the end of the intervention

Trial Locations

Locations (1)

University of Cincinnati; 🇺🇸 Cincinnati, Ohio, United States