Role of connective tissue growth factor in peritoneal fibrosis and encapsulating peritoneal sclerosis
Completed
- Conditions
- encapsulating peritoneal sclerosis10034652peritoneal fibrosis10038430
- Registration Number
- NL-OMON32262
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
Patients with ESRD who are about to undergo a kidney transplantation in the University Medical Centre Utrecht.
Exclusion Criteria
Patients who are unable to give informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are thickness of the peritoneal submesothelial<br /><br>compact zone, CTGF mRNA and protein expression in the peritoneum, and CTGF<br /><br>levels in plasma, urine, and peritoneal effluent. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters are the degree of vasculopathy in the<br /><br>peritoneum, TGF-β1 and VEGF mRNA and protein expression in the peritoneum, and<br /><br>TGF-β1 and VEGF levels in plasma, urine, and peritoneal effluent. </p><br>