CTRI/2023/10/058236招募中3 期
Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior Decompensation, an Open Label Randomised Control Trial. - NI
试验速览
- 阶段
- 3 期
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Age 18-70 years
- •2.Cirrhosis with prior clinical decompensation (ascites, Hepatic encephalopathy, Portal Hypertension related bleed)
- •3.No current clinical decompensation (for at least 1 year)
- •4.CTP A at enrollment
排除标准
- •1. Post TIPS/ BRTO/ SAE patients
- •2. Post renal or liver transplantation
- •3. History of CAD, ischemic cardiomyopathy, PVD, ventricular arrythmia
- •4. Presence of clinical ascites, HE, Jaundice
- •5. Last clinical decompensation within 3 months
- •6. Ongoing significant alcohol use
- •7. Active HCV/HBV infection (Detectable HCV RNA/ HBV DNA)
- •8. Prior Intolerance to carvedilol and hypersensitivity to Pentoxyfylline
- •9. Use of Pentoxifylline within last 1 month
- •10.AIH/ PBC
- •11.Lack of informed consent
- •12.Hepatocellular carcinoma / Portal vein thrombosis/ Budd Chiari Syndrome
- •13.Non-cirrhotic portal hypertension
- •14.Ongoing CAM/Hepatotoxic drug intake
- •15.Known HIV infection
- •16.Pregnant women
- •17.Hepato Pulmonary Syndrome
研究者
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