NL-OMON51854
Not yet recruiting
Not Applicable
on-invasive preimplantation genetic testing (niPGT) - haplotyping by sequencing embryo spent culture medium - non-invasive preimplantation genetic testing (niPGT)
Medisch Universitair Ziekenhuis Maastricht0 sites317 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- chromosomal anomalies
- Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Enrollment
- 317
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Group inclusion criteria:
- •To be eligible to participate in this study, a couple must meet all of the
- •following criteria:
- •Couples that have or are carrier of a known severe genetic disorder that choose
- •to do in vitro fertilization (IVF) following preimplantation genetic testing
- •(PGT\-IVF). Inclusion criteria of couples are similar to inclusion criteria from
- •PGT that are the following:
- •o The offspring have a high risk on inheriting a severe genetic disorder (as
- •nationally determined by national indication committee); PGT\-M.
- •o There is a high risk of miscarriage due to an unbalanced translocation or a
Exclusion Criteria
- •Group exclusion criteria:
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study.
- •Couples unable to give informed consent to any of the study aspects or unable
- •to comply with the protocol
- •o When participants are \< 18 years
- •o Couples that do not speak Dutch will be excluded from participation in this
- •IVF/PGD treatment for a mitochondrial disorder (linked to mtDNA).
- •The analysis of the embryos is done using a day 3 biopsy and subsequent
- •fluorescence in situ hybridization (FISH) analysis.
Outcomes
Primary Outcomes
Not specified
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