Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Phase 1

Completed

• Conditions: Dental Plaque
• Interventions: Drug: Chlorhexidine mouthwash; Other: Natural honey

• Registration Number: NCT05258955
• Lead Sponsor: Liaquat National Hospital & Medical College

Brief Summary

The rationale of our study is to compare the efficacy of natural honey base preparation with other commercially available mouthwashes i.e chlorhexidine base in prevention of dental plaque formation as honey is readily available and cost effective and organic in nature. This study will help to provide the data of our community and positive result may provide a new method of oral hygiene maintenance with fewer side effects. We will be able to deliver the best anti-plaque agent.

Detailed Description

In this study, participants will assigned into 2 group those who will fulfilled the inclusion and exclusion criteria. After the informed consent, they were divided into 2 group. Group A will received Chlorhexidine mouthwash and Group B will provided with honey based mouthwash. The participant will blinded as solution will be provided in dark color bottle to mask the study. After which the baseline plaque index will be taken followed by recording plaque index on 7th, 14th, and 21st day. The statistical analysis will be done to compare the mean difference between these 2 groups

Study Timeline

• Study Start: 2020-06-03
• Primary Completion: 2020-12-30
• Study Completion: 2021-01-21
• Status Verified: 2022-02
• Study First Submitted: 2022-02-17
• Study First Submitted QC: 2022-02-17
• Last Update Submitted: 2022-02-17
• Study First Posted: 2022-02-28
• Last Update Posted: 2022-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Individual aged between 18-25
2. Retained 28 number of teeth excluding wisdom teeth

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Exclusion Criteria

1. Individual with medical illness affecting oral cavity like diabetes, sjögren syndrome, crohn disease etc
2. Multiple extraction , overhang restoration, wearing any appliance
3. Periodontal problem with pocket depth more than 3mm
4. Current or recent history of antibiotic consumption
5. Noncompliance that is unable to maintain their hygiene.
6. Pan, Betel quid and any other oral habit will not be included in study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Chlorhexidine	Chlorhexidine mouthwash	these are the group which received chlorhexidine based preparation for plaque reduction
Natural honey	Natural honey	these group will received the honey base mouthwash and the its effect on plaque reduction will be observed in follow up visits

Primary Outcome Measures

Name	Time	Method
Dental Plaque	reduction of plaque index will be assessed on 7th day, 14th day and on 21st day	primary outcome is to assessed the reduction on plaque level among Group A and Group B

Trial Locations

Locations (1)

Liaquat College of Medicine and Dentistry; 🇵🇰 Karachi, Sindh, Pakistan