Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation

Completed

• Conditions: Inflammation; Dermatomyositis; Myocardial Repolarization
• Interventions: Other: disease

• Registration Number: NCT06002750
• Lead Sponsor: The Third People's Hospital of Hangzhou

Brief Summary

The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are:

* 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients;

* 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-24
• Primary Completion: 2022-11-23
• Study Completion: 2022-11-24
• Study First Submitted: 2023-08-16
• Study First Submitted QC: 2023-08-16
• Study First Posted: 2023-08-21
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-19
• Last Update Posted: 2025-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form.

Clinical diagnosis of Dermatomyositis.

Exclusion Criteria

Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women.

Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc.

Patients with severe lack of case data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dermatomyositis patients	disease	-

Primary Outcome Measures

Name	Time	Method
the Tp-e interval and Tp-e/QT ratio were positively correlated with Inflammation.	November 2011 to November 2022
QTc, Tp-e interval, and Tp-e/QT ratio were increased in DM patients.	November 2011 to November 2022

Trial Locations

Locations (1)

The Third People's Hospital of Hangzhou; 🇨🇳 Zhejiang, Hangzhou, China