The Brain Network Mechanism and Outcome After Surgical Intervention of Conductive Hearing Loss Accompanied by Tinnitus.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Conductive Hearing Loss
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- speech test
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This study explores the brain region activation and remodeling of poor connections of brain regions in the postoperative outcomes of conductive hearing loss patients with tinnitus by comparing pre - and post-operative audiological assessment, tinnitus assessment and EEG data.
Detailed Description
This study explores the brain region activation and remodeling of poor connections of brain regions in the postoperative outcomes of conductive hearing loss patients with tinnitus by comparing pre - and post-operative audiological assessment, tinnitus assessment and EEG data. Including audiological assessment (pure tone audiometry, speech test), tinnitus assessment (tinnitus matching, tinnitus handicap inventory, tinnitus function index, visual analogue scale)and non-invasive brain imaging assessment (EEG, fNIRS).
Investigators
Eligibility Criteria
Inclusion Criteria
- •aged between 18 and 60 years;
- •diagnosed with conductive hearing loss with tinnitus;
- •treated with surgery;
- •able to cooperate with all Chinese version evaluation;
- •right-handed.
Exclusion Criteria
- •Pure tone audiometry indicates that the average pure tone hearing threshold (500Hz, 1kHz, 2kHz, 4kHz) is \> 91dB HL;
- •acoustic neuroma, nasopharyngeal carcinoma;
- •hearing loss caused by noise or drugs.
Outcomes
Primary Outcomes
speech test
Time Frame: 3-7 days before surgery, 1-12 months after surgery
Speech audiometry was mainly used to analyze the speech recognition rate of patients before and after surgery
pure tone audiometry
Time Frame: 3-7 days before surgery, 1-12 months after surgery
The air- conducted threshold, bone-conducted threshold and air- bone gap of each frequency of pure tone audiometry were used to compare pre - and post-operative hearing level.
EEG activation
Time Frame: 3-7 days before surgery, 1-12 months after surgery
EEG signals were used to explore the activation of brain regions and remodeling of poor connections in the postoperative outcomes of conductive hearing loss patients accompanied by with tinnitus. Power spectral density calculation, traceability analysis, functional connection, microstate, clustering coefficient, feature path length, feature path intermediation, and isocompatibility coefficient were collected and then analyzed.
tinnitus handicap inventory scores
Time Frame: 3-7 days before surgery, 1-12 months after surgery
The total score of the THI scale and the scores of the three subscales(functional, emotional, and catastrophic) were collected before and after surgery for data analysis.
Secondary Outcomes
- fNIRS activation(3-7 days before surgery, 1-12 months after surgery)
- tinnitus function index scores(3-7 days before surgery, 1-12 months after surgery)
- visual analogue scale(3-7 days before surgery, 1-12 months after surgery)