Effect of Glutathione on Blood Alcohol and Hangover Symptoms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
研究概览
简要总结
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.
As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.
In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.
The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.
详细描述
Type of Study: Double-blinded control
Population: 100 males
Inclusion Criteria:
- Males 20-40 years
- Healthy, without chronic diseases, especially must have normal hepatic function, measured by serum SGPT
- No history of alcoholic allergy
- Drink alcohol regularly, at least once a week
- Agree to be a subject by standard consent form
Exclusion Criteria:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Males 20-40 years old
- •No allergies to alcohol
排除标准
- •Chronic disease
- •Increase in hepatic enzyme SGPT
- •Impending danger