Diagnostic Role of Serum Testican and Ubiquitin Levels in Patients With Head Trauma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 89
- 试验地点
- 1
- 主要终点
- Comparison of testican-1 and ubiquitin levels in patients with moderate traumatic brain injuries and a control group
研究概览
简要总结
We aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury.
详细描述
The study specifically included patients over 18 years of age with moderate TBI (GCS: 9-13) who provided informed consent. The control group consisted of healthy individuals without any disease who voluntarily participated in the study. Patients with moderate TBI were divided into two groups: those with intracranial pathology (Subdural hemorrhage, epidural hemorrhage, subarachnoid hemorrhage, intraparenchymal hemorrhage, and contusion) and those without. Treatment was initiated according to ATLS in patients with moderate TBI, and blood samples taken at the time of admission to the emergency department were placed in Ethylenediaminetetraacetic acid (EDTA) tubes. The relationship between the patient's clinical scoring (GCS, ISS and AIS), brain CT results, and mortality status with testican-1 and ubiquitin levels was compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •being over 18 years old
- •having a GCS score between 9 and 13
排除标准
- •under 18 years of age
- •had missing data
- •were pregnant
- •had neurodegenerative disease
- •had Central Nervous System (CNS) infection
- •had cerebral palsy
- •had penetrating head injury (by a cutting or piercing tool such as a firearm, knife, axe)
- •patients with severe (GCS: 3-8) or mild (GCS: 14-15) TBI
结局指标
主要结局
Comparison of testican-1 and ubiquitin levels in patients with moderate traumatic brain injuries and a control group
时间窗: The study was conducted with blood samples taken at the time of admission.
We compared the plasma blood levels of biomarkers in both groups
次要结局
- ROC curve analysis for the prediction of intraparenchymal pathology (+)(The study was conducted with blood samples taken at the time of admission.)
研究者
Ramiz Yazıcı
Assistant Professor
Kanuni Sultan Suleyman Training and Research Hospital